illumination wrote: ↑Mon Dec 02, 2019 8:54 pm
TN_Boy wrote: ↑Mon Dec 02, 2019 7:47 pm
illumination wrote: ↑Mon Dec 02, 2019 12:25 pm
TN_Boy wrote: ↑Mon Dec 02, 2019 11:31 am
illumination wrote: ↑Mon Dec 02, 2019 11:23 am
There's already treatments that slow down the production of the amyloid plague formation and how the brain reacts to it. They've also used these treatments in plague formation around organs like the heart that make an enormous difference. I could see treatments beings something like Lipitor/statins where you take it and it helps reduce the chance of having that plague build up.
It's probably not something on the horizon where someone who already is deep into Alzheimers is going to be cured (just like someone who has AIDS isn't probably going to take a pill and not have it anymore) but I see definitely could see a treatment in my lifetime where it could be reduced to where it keeps a lot of people out of of these facilities.
I just know when my grandmother had to go to a facility, she was otherwise quite healthy, but her brain was not, started doing dangerous things like wandering her neighborhood. I think that probably describes a lot of people that have to go to places like that for long term care. If you could dramatically slow that down, it would make a big difference.
"There's already treatments that slow down the production of the amyloid plague formation and how the brain reacts to it. "
? But those treatments haven't been shown to actually, like, help right?
I realize there is a thought that maybe if you start really early with this sort of treatments (before symptoms develop) that it might help, but from what I read, that is more wishful thinking than anything else. No hard evidence yet. Just a failure of all clinical trials thus far .....
There's a slew of medications that slow down the symptoms, there isn't anything that can reverse the plague yet, that's sort of the Holy Grail.
But keeping the plague from developing before it gets there I would say could be a game changer for people that don't have it yet.
I still think these developments are far closer than A.I. making a big impact on long term care. I guess we'll have to just wait and see.
Certainly preventing or curing Alzheimers (and ideally the other dementias) would have a huge impact on long term care costs.
But as you correctly said above, while there are some medications that may help alleviate Alzheimer
symptoms, we currently have nothing that even slows the progression of the disease itself, much less reverse or cure it.
I've been reading about "advances" in Alzheimer research for over a decade now, and I'm not too impressed. Not to denigrate the researchers; obviously this is a very hard problem. But we keep trying drugs that fail, and people thought they "understood" the disease before.
As a layperson, I'm skeptical the amyloid hypothesis is correct; you'd think they would have come up with at least some limited success by now, the idea has been around for 25 years. They are now doing trials with younger people who don't have Alzheimer's to prove or disprove the theory that if you just go after the amyloid early enough it will help.
Here's a nice summary about the amyloid hypothesis and some other theories:
https://www.nature.com/articles/d41586-018-05719-4
That said, I sure hope your friends are right!
You really seem to be against the idea that we will ever make any progress with Alzheimers or dementia. Did you get burned on some Biotech stock or something?
Chuckle. No biotech stock mishaps. My dismal outlook on Alzheimer's research is pretty well summed up by the information in the article I linked. Most of the research thus far has focused on the amyloid hypothesis. That is, most trials, and I think most of the research money. (This is not news, there have been reports/articles pointing out the lack of progress in this approach for years).
Now maybe the idea that drugs taken for years before symptoms* develop will pan out and we'll have something. But if that idea fails, we are left with the fact that work based on the amyloid hypothesis has resulted in 0 useful treatments. 0 is very bad. You'd think if this was the right idea there would have been successes. Even minor ones. Nope, 100% complete failure. Given the number of drug trials, this should give anyone pause.
But every year some new ideas come out and hopefully some of them will prove fruitful.
The other part of my cynicism (mind you, I"d rather be wrong on this ....) is based on cancer research. We've been spending a lot of money fighting cancer a long time. And there have been some big successes (unlike Alzheimer's). But if you get pancreatic cancer, for example, you should be sure your affairs are in order, because the five year survival rate hasn't moved much and it's really low.
* interestingly, you mentioned statins, in fact studies show that over a larger population, statins provide very minimal increases in average lifespan extension (i.e. death by all causes). Most people taking statins will live little, if any, longer than if they had never taken them. A rather small subset of people will get a more significant benefit.