First off I'd like to say I've enjoyed reading this forum and have just spent about 2 hours reading posts about Restricted Stock Units and have got up to speed on most topics.
My filing situation is married filing jointly, we make about $400K total each year on W2 salary. I am fortunate and have RSU in a growing company, each year I'm getting about the same amount of RSU granted, let's say around $50K a year and each grant vests 1/4 per year. So every year I get 4 tranches of grants for a total of $50K (grant) + appreciation (at vest) and this year on Box 14 of my W2 the RESTK is $93K. My company takes out ~%25 to cover taxes upon vest but its not nearly enough, this is a company wide policy and they don't adjust the % for individuals.
All of my vested RSU is worth $450K and my cost basis is $225K, I have no tranches with negative cost basis, I've never sold any RSU. I'm looking at $225K of LT cap gains. I now know that about 95% of Bogleheads would say to sell that RSU at vesting and diversify it, I'm prepared to change my ways.
OK, enough back story.
My main issue over the past few years is that we owe a lot of money to the IRS every year. Last year was $24K and this year is like $35K. Paying it out of our checking account and my bonus, I don't want to do this any longer, I should be able to use my investments to pay for my investments

In addition to wanting to start taking some vested RSU off the table I want to sell another chunk of Vanguard too-heavy-in-bond/dividend funds this year as well and will see more cap gains.
I have read to not let the "tax tail wag the dog" and I'm thinking that I'm going to have to be more aggressive in selling RSU to cover W2 taxes (so I don't pay from my checking/bonus) and I also need to diversify out of the RSU.
Questions:
* For my next Vanguard (sell) ---> Vanguard (buy) what's the best way to prepare to cover cap gains taxes? Should I take 25% of my sale and send it straight to my high interest savings account to cover 1099-B taxes at tax time?
* When my RSU vest should I immediately take another %25 and put in in high interest savings for tax time for W2?
* When I sell my RSU, is it safe to take %25 of capital gains and put it in high interest savings for tax time for 1099-B?
Hope this is not too long, Thanks.