https://www.dailymail.co.uk/health/arti ... laims.html
A virus which is too aggressive may burn itself out by landing patients in hospital
A virus which is too aggressive may burn itself out by landing patients in hospital
It certainly seemed that way as some of the data began to accumulate. Maybe when things are really calmed down they'll figure it out in more detail.MtnBiker wrote: ↑Wed Mar 04, 2020 12:53 pm Initial report from researchers in China is that the coronavirus in Wuhan was primarily a more aggressive type. Potential good news if this preliminary data can be confirmed, and if the more aggressive strain can be contained:
https://www.dailymail.co.uk/health/arti ... laims.html
A virus which is too aggressive may burn itself out by landing patients in hospital
I have retired colleagues in Florida where it is very popular.Unladen_Swallow wrote: ↑Sun Mar 01, 2020 3:15 pm Now I'm curious - what is pickleball? I think I ought to take it up.
Here is something to think about.
Preach.knpstr wrote: ↑Wed Mar 04, 2020 1:57 pmHere is something to think about.
What if you already had it a month ago and never knew it because you just had a runny nose and a sore throat?
You didn't seek medical attention because it was "just a cold".
The vast majority of people that have symptoms will experience just that, something along the lines of a normal "coronavirus" infection, thinking nothing else of it.
They may get it, never seek treatment, recover - yet sit fearful in their homes "hoping to never get it".
And others who think they just have a cold and this whole thing is hysteria and is no big deal, may visit their grandparents, hug and kiss them, and then one or both grandparents wind up needing a ventilator. The risk of this happening with COVID-19 appears to be much higher than with our usual cold and flu bugs.Galaxy8 wrote: ↑Wed Mar 04, 2020 1:58 pmPreach.knpstr wrote: ↑Wed Mar 04, 2020 1:57 pmHere is something to think about.
What if you already had it a month ago and never knew it because you just had a runny nose and a sore throat?
You didn't seek medical attention because it was "just a cold".
The vast majority of people that have symptoms will experience just that, something along the lines of a normal "coronavirus" infection, thinking nothing else of it.
They may get it, never seek treatment, recover - yet sit fearful in their homes "hoping to never get it".
https://www.cato.org/blog/misleading-ar ... eath-ratesAssuming the number of people who have reportedly died from COVID-19 is reasonably accurate, then the percentage of infected people who die from the disease (the death rate) must surely have been much lower than the 2–3% estimates commonly reported. That is because the number of infected people is much larger than the number tested and reported.
...
A Chinese study in the Journal of the American Medical Association, February 20, found a “case‐fatality rate” of 2.3%, meaning 1,023 died out of 44,672 cases. But the total sample in that study (72,314) included an additional 27,642 non‐confirmed cases, and simply including cases (let alone unreported minor cases) would have reduced the fatality rate to 1.4%. China‐based estimates are largely confined to cases with the most severe symptoms, so it should be no surprise that the reported death rate among severe cases is much higher than it would be if the data also included “most people” who “have a mild disease and get better.” The risk of infecting more people is also more severe in China data, since severe cases are concentrated and transmitted in hospitals. This can also lead to overstated estimates of how many people are infected by someone with COVID-19, including the WHO “reproduction number” estimate of 1.4–2.5, which is mainly based on evidence from China.
By the morning of March 2, there had been 89,253 confirmed cases of COVID-19 reported around the world, with about 96% of those in Asia. For comparison, the were an estimated 37.9 million people living with HIV in 2018.
It is worth noting that have also been 45,393 known recoveries from COVID-19 (compared to 3048 cumulative deaths) and, importantly, recoveries have been outnumbering new cases.
The article is written by an uninformed journalist.CT-Scott wrote: ↑Wed Mar 04, 2020 12:21 pmJust to follow-up on this since the headline of the article I posted the link to used the term "death rate", if you read the article they appear to use proper terminology. Here's are some snippets:World health officials say the mortality rate for COVID-19 is 3.4% globally, higher than previous estimates of about 2%.Now, that said, the *vast* majority of the cases are still from China, so as this continues to spread, I fully expect that the mortality rate numbers will continue to be revised.“Globally, about 3.4% of reported COVID-19 cases have died,” WHO Director-General Tedros Adhanom Ghebreyesus said during a press briefing at the agency’s headquarters in Geneva.
I think it's worse than typical flu. The virus appears to have come from a cave picked up from a bat. Who knows what's lurking in some of these caves.
Unladen_Swallow,Unladen_Swallow wrote: ↑Wed Mar 04, 2020 2:14 pm "The Misleading Arithmetic of Covid-19 Death rates"
https://www.cato.org/blog/misleading-ar ... eath-ratesAssuming the number of people who have reportedly died from COVID-19 is reasonably accurate, then the percentage of infected people who die from the disease (the death rate) must surely have been much lower than the 2–3% estimates commonly reported. That is because the number of infected people is much larger than the number tested and reported.
...
A Chinese study in the Journal of the American Medical Association, February 20, found a “case‐fatality rate” of 2.3%, meaning 1,023 died out of 44,672 cases. But the total sample in that study (72,314) included an additional 27,642 non‐confirmed cases, and simply including cases (let alone unreported minor cases) would have reduced the fatality rate to 1.4%. China‐based estimates are largely confined to cases with the most severe symptoms, so it should be no surprise that the reported death rate among severe cases is much higher than it would be if the data also included “most people” who “have a mild disease and get better.” The risk of infecting more people is also more severe in China data, since severe cases are concentrated and transmitted in hospitals. This can also lead to overstated estimates of how many people are infected by someone with COVID-19, including the WHO “reproduction number” estimate of 1.4–2.5, which is mainly based on evidence from China.
By the morning of March 2, there had been 89,253 confirmed cases of COVID-19 reported around the world, with about 96% of those in Asia. For comparison, the were an estimated 37.9 million people living with HIV in 2018.
It is worth noting that have also been 45,393 known recoveries from COVID-19 (compared to 3048 cumulative deaths) and, importantly, recoveries have been outnumbering new cases.
What kind of terrible person visits their grandparents hugs/kisses them while they have an active "cold" under any circumstances?!clip651 wrote: ↑Wed Mar 04, 2020 2:11 pm And others who think they just have a cold and this whole thing is hysteria and is no big deal, may visit their grandparents, hug and kiss them, and then one or both grandparents wind up needing a ventilator. The risk of this happening with COVID-19 appears to be much higher than with our usual cold and flu bugs.
Have they shutdown all businesses?Irisheyes wrote: ↑Wed Mar 04, 2020 2:26 pm Italy as of today, 3090 cases, with 107 deaths.
They have closed ALL schools and universities.
https://www.theguardian.com/world/2020/ ... oronavirus
article is not behind a paywall.knpstr wrote: ↑Wed Mar 04, 2020 2:30 pmHave they shutdown all businesses?Irisheyes wrote: ↑Wed Mar 04, 2020 2:26 pm Italy as of today, 3090 cases, with 107 deaths.
They have closed ALL schools and universities.
https://www.theguardian.com/world/2020/ ... oronavirus
Klangfool,KlangFool wrote: ↑Wed Mar 04, 2020 2:24 pmUnladen_Swallow,Unladen_Swallow wrote: ↑Wed Mar 04, 2020 2:14 pm "The Misleading Arithmetic of Covid-19 Death rates"
https://www.cato.org/blog/misleading-ar ... eath-ratesAssuming the number of people who have reportedly died from COVID-19 is reasonably accurate, then the percentage of infected people who die from the disease (the death rate) must surely have been much lower than the 2–3% estimates commonly reported. That is because the number of infected people is much larger than the number tested and reported.
...
A Chinese study in the Journal of the American Medical Association, February 20, found a “case‐fatality rate” of 2.3%, meaning 1,023 died out of 44,672 cases. But the total sample in that study (72,314) included an additional 27,642 non‐confirmed cases, and simply including cases (let alone unreported minor cases) would have reduced the fatality rate to 1.4%. China‐based estimates are largely confined to cases with the most severe symptoms, so it should be no surprise that the reported death rate among severe cases is much higher than it would be if the data also included “most people” who “have a mild disease and get better.” The risk of infecting more people is also more severe in China data, since severe cases are concentrated and transmitted in hospitals. This can also lead to overstated estimates of how many people are infected by someone with COVID-19, including the WHO “reproduction number” estimate of 1.4–2.5, which is mainly based on evidence from China.
By the morning of March 2, there had been 89,253 confirmed cases of COVID-19 reported around the world, with about 96% of those in Asia. For comparison, the were an estimated 37.9 million people living with HIV in 2018.
It is worth noting that have also been 45,393 known recoveries from COVID-19 (compared to 3048 cumulative deaths) and, importantly, recoveries have been outnumbering new cases.
In summary, you believe the numbers reported by China. And, you believe that China would shut down her economy for a few thousand deaths. If my interpretation of your post is wrong, please correct me.
KlangFool
Is this a serious question? I'm curious how young you might be, as it seems like you have a lot fewer years of life-experience than I do. Or maybe you're from a particular ethnicity/culture where people are especially conscious/considerate about that sort of thing. In my experience, I've frequently encountered a much more cavalier attitude when someone thinks they just have a cold. They will not change their normal activity as a result of "just" having a cold. They may avoid seeing an elderly parent/grandparent who is ill, but often will not avoid seeing them otherwise.
Sorry to be pedantic, but it is Case Fatality Ratio, not rate. I sometimes type the same mistake.
I'm in my mid 30s.CT-Scott wrote: ↑Wed Mar 04, 2020 2:43 pmIs this a serious question? I'm curious how young you might be, as it seems like you have a lot fewer years of life-experience than I do. Or maybe you're from a particular ethnicity/culture where people are especially conscious/considerate about that sort of thing. In my experience, I've frequently encountered a much more cavalier attitude when someone thinks they just have a cold. They will not change their normal activity as a result of "just" having a cold. They may avoid seeing an elderly parent/grandparent who is ill, but often will not avoid seeing them otherwise.
I sure wish South Korea would start reporting accurate records on the number of recovered. To date they report 5621 cases, 35 deaths, and 41 recovered. So the case recovery ratio, recovered/(recovered + deaths), is 54% ?
https://nypost.com/2020/03/04/chinese-r ... ng-people/The preliminary study, conducted by researchers from Peking University’s School of Life Sciences and the Institute Pasteur of Shanghai under the Chinese Academy of Sciences, revealed that the infection has evolved into two major types, designated L and S.
The L type, which is more aggressive, was more prevalent during the early stages of the outbreak in Wuhan — the original epicenter of the virus — and accounted for about 70 percent of analyzed strains . About 30 percent of those strains were linked to the S type, considered less aggressive.
The prevalence of the L type decreased after early January, researchers found.
...
“If the L type is more aggressive than the S type, why did the relative frequency of the L type decrease compared to the S type in other places after the initial breakout in Wuhan?” they wrote. “One possible explanation is that, since January 2020, the Chinese central and local governments have taken rapid and comprehensive prevention and control measures.”
“These human intervention efforts might have caused severe selective pressure against the L type, which might be more aggressive and spread more quickly,” they explained. “The S type, on the other hand, might have experienced weaker selective pressure by human intervention, leading to an increase in its relative abundance among the SARS-CoV-2 viruses.”
Seems intuitive to me. When I have a cold, I especially avoid kids and elders, and contact with others until I am better. I excuse myself from handshakes, hugs etc.knpstr wrote: ↑Wed Mar 04, 2020 3:01 pm
I'm in my mid 30s.
My father and myself and all of my siblings are all in the healthcare field.
Perhaps we are more cognizant of our health than the average person, but it is reckless to kiss your grandparents (or anyone who may have a compromised immune system) while you are sick -- even with the "common cold".
As a matter of fact, I don't kiss my wife/child when I'm sick and vice versa. If you love someone why would you want to risk even giving them a cold? Seems like common sense to me, but perhaps it isn't.
The questions in the current moment properly revolve first and foremost around public-health strategy. But there is much for economic policymakers to consider as well. Unfortunately, the tool that has received the most attention — monetary policy — is not likely to be very effective in a crisis of this kind, and the way it’s used could create problems down the road. It may on balance be desirable to cut interest rates — as the Fed voted to do Tuesday ― but the principal focus should be elsewhere.
And maybe most importantly:But when GDP falls because businesses cannot get components necessary to generate output, because quarantines limit people’s ability to work and because potential customers are rationally afraid to enter public spaces, then monetary policy is much less useful.
There are also tactical issues to consider. The hardest moments for economic policymakers are when the power of the tool at their disposal is less than what is generally supposed. In such a circumstance, policy can function better as a potentially potent “sword of Damocles” than it would if its limited efficacy were laid bare. Closely related to this is the idea of never shooting your last bullet. And to the almost inevitable extent that it would appear political, a sharp move to easy money may undercut the Fed’s credibility.
Viral multiplication/mutation results in various strains , eventually antigenic drifts and shiftsUnladen_Swallow wrote: ↑Wed Mar 04, 2020 3:05 pm Chinese researchers say 2 types of coronavirus could be infecting people
...
My wife and I are with you two, though I've traditionally been much less of a germaphobe than my wife, such that I typically have never "worried" about coming in contact with someone else who has a cold, when I do not. When I am sick (even with just a cold) I try to avoid exposing anyone else, especially the elderly. *BUT* what I haven't ever done was to stop going out in public, grocery shopping, or "quarantining" myself when I think I just have a cold, and if I can be a carrier showing only "common cold" symptoms, but actually be a carrier for Coronavirus, then I'd likely be spreading it in those places, such that an elderly person could be exposed unintentionally.Unladen_Swallow wrote: ↑Wed Mar 04, 2020 3:10 pmSeems intuitive to me. When I have a cold, I especially avoid kids and elders, and contact with others until I am better. I excuse myself from handshakes, hugs etc.knpstr wrote: ↑Wed Mar 04, 2020 3:01 pm
I'm in my mid 30s.
My father and myself and all of my siblings are all in the healthcare field.
Perhaps we are more cognizant of our health than the average person, but it is reckless to kiss your grandparents (or anyone who may have a compromised immune system) while you are sick -- even with the "common cold".
As a matter of fact, I don't kiss my wife/child when I'm sick and vice versa. If you love someone why would you want to risk even giving them a cold? Seems like common sense to me, but perhaps it isn't.
Per https://en.wikipedia.org/wiki/Case_fatality_rate:
There were two prominent genotypes in Wuhan, one of which emerged rather rapidly and seems to be associated with about 70% of their serve cases.
I am not a germaphobe at all. Not one bit. But I am cognizant of others...they don't need my germs.CT-Scott wrote: ↑Wed Mar 04, 2020 3:26 pmMy wife and I are with you two, though I've traditionally been much less of a germaphobe than my wife, such that I typically have never "worried" about coming in contact with someone else who has a cold, when I do not. When I am sick (even with just a cold) I try to avoid exposing anyone else, especially the elderly. *BUT* what I haven't ever done was to stop going out in public, grocery shopping, or "quarantining" myself when I think I just have a cold, and if I can be a carrier showing only "common cold" symptoms, but actually be a carrier for Coronavirus, then I'd likely be spreading it in those places, such that an elderly person could be exposed unintentionally.Unladen_Swallow wrote: ↑Wed Mar 04, 2020 3:10 pmSeems intuitive to me. When I have a cold, I especially avoid kids and elders, and contact with others until I am better. I excuse myself from handshakes, hugs etc.knpstr wrote: ↑Wed Mar 04, 2020 3:01 pm
I'm in my mid 30s.
My father and myself and all of my siblings are all in the healthcare field.
Perhaps we are more cognizant of our health than the average person, but it is reckless to kiss your grandparents (or anyone who may have a compromised immune system) while you are sick -- even with the "common cold".
As a matter of fact, I don't kiss my wife/child when I'm sick and vice versa. If you love someone why would you want to risk even giving them a cold? Seems like common sense to me, but perhaps it isn't.
Coronaviruses don't shift. They can drift and they can undergo recombination, but not shift (reassortment).kksmom wrote: ↑Wed Mar 04, 2020 3:26 pmViral multiplication/mutation results in various strains , eventually antigenic drifts and shiftsUnladen_Swallow wrote: ↑Wed Mar 04, 2020 3:05 pm Chinese researchers say 2 types of coronavirus could be infecting people
...
No, what laymen mean by death rate is mortality. Laymen are unaware of the difference between CFR and mortality.JonnyB wrote: ↑Wed Mar 04, 2020 2:16 pmThe article is written by an uninformed journalist.
"World health officials say the mortality rate for COVID-19 is 3.4%"
This is not a quote because the WHO would never say something like that. The number quoted is the CFR, Case Fatality Ratio. The word mortality was added by the journalist, which is an error.
"Globally, about 3.4% of reported COVID-19 cases have died"
That is what WHO actually said, without the word mortality. That is the CFR.
Death rate is a layman's term. Generally what laymen mean by death rate is CFR, Case Fatality Ratio, not mortality.
Im pretty sure you are the exception, not the norm.knpstr wrote: ↑Wed Mar 04, 2020 3:01 pmI'm in my mid 30s.CT-Scott wrote: ↑Wed Mar 04, 2020 2:43 pmIs this a serious question? I'm curious how young you might be, as it seems like you have a lot fewer years of life-experience than I do. Or maybe you're from a particular ethnicity/culture where people are especially conscious/considerate about that sort of thing. In my experience, I've frequently encountered a much more cavalier attitude when someone thinks they just have a cold. They will not change their normal activity as a result of "just" having a cold. They may avoid seeing an elderly parent/grandparent who is ill, but often will not avoid seeing them otherwise.
My father and myself and all of my siblings are all in the healthcare field.
Perhaps we are more cognizant of our health than the average person, but it is reckless to kiss your grandparents (or anyone who may have a compromised immune system) while you are sick -- even with the "common cold".
As a matter of fact, I don't kiss my wife/child when I'm sick and vice versa. If you love someone why would you want to risk even giving them a cold? Seems like common sense to me, but perhaps it isn't.
Tony-S wrote: ↑Wed Mar 04, 2020 3:43 pmCoronaviruses don't shift. They can drift and they can undergo recombination, but not shift (reassortment).kksmom wrote: ↑Wed Mar 04, 2020 3:26 pmViral multiplication/mutation results in various strains , eventually antigenic drifts and shiftsUnladen_Swallow wrote: ↑Wed Mar 04, 2020 3:05 pm Chinese researchers say 2 types of coronavirus could be infecting people
...
"Shift" only occurs in RNA viruses with segmented genomes (e.g., orthomyxo, reo, bunya and arenaviruses). Co-infection of a cell with two viruses of the same or similar species leads to reassortment, which is what "shift" is. For example, influenza A viruses (orthomyxoviruses) have 8 segments of RNA. If a cell is infected with two distinct influenza A viruses, then the possible reassortment of these 8 segments is 2^8 (256). Coronaviruses have only a single piece of RNA for their genomes, thus reassortment cannot occur.kksmom wrote: ↑Wed Mar 04, 2020 4:00 pmWould appreciate references to explanations as to why "Coronaviruses don't shift".Tony-S wrote: ↑Wed Mar 04, 2020 3:43 pmCoronaviruses don't shift. They can drift and they can undergo recombination, but not shift (reassortment).kksmom wrote: ↑Wed Mar 04, 2020 3:26 pmViral multiplication/mutation results in various strains , eventually antigenic drifts and shiftsUnladen_Swallow wrote: ↑Wed Mar 04, 2020 3:05 pm Chinese researchers say 2 types of coronavirus could be infecting people
...
Thanks
Tony-S wrote: ↑Wed Mar 04, 2020 4:11 pm"Shift" only occurs in RNA viruses with segmented genomes (e.g., orthomyxo, reo, bunya and arenaviruses). Co-infection of a cell with two viruses of the same or similar species leads to reassortment, which is what "shift" is. For example, influenza A viruses (orthomyxoviruses) have 8 segments of RNA. If a cell is infected with two distinct influenza A viruses, then the possible reassortment of these 8 segments is 2^8 (256). Coronaviruses have only a single piece of RNA for their genomes, thus reassortment cannot occur.kksmom wrote: ↑Wed Mar 04, 2020 4:00 pmWould appreciate references to explanations as to why "Coronaviruses don't shift".Tony-S wrote: ↑Wed Mar 04, 2020 3:43 pmCoronaviruses don't shift. They can drift and they can undergo recombination, but not shift (reassortment).kksmom wrote: ↑Wed Mar 04, 2020 3:26 pmViral multiplication/mutation results in various strains , eventually antigenic drifts and shiftsUnladen_Swallow wrote: ↑Wed Mar 04, 2020 3:05 pm Chinese researchers say 2 types of coronavirus could be infecting people
...
Thanks
Exposure to cold/flu viruses when young yield a stronger immune system with more antibodies when old. Even getting a different virus/illness later in life, if you've been exposed to something similar before, the effects are often lessened.
No one is put in bubbles.UpsetRaptor wrote: ↑Wed Mar 04, 2020 4:41 pm
Exposure to cold/flu viruses when young yield a stronger immune system with more antibodies when old. Even getting a different virus/illness later in life, if you've been exposed to something similar before, the effects are often lessened.
I wouldn't intentionally give someone an illness, but too much sheltering can be detrimental long term as well. As with many things health-related, a reasonable middle ground is often best.
I'm sorry, but you have this exactly backwards.HomerJ wrote: ↑Wed Mar 04, 2020 3:58 pmNo, what laymen mean by death rate is mortality. Laymen are unaware of the difference between CFR and mortality.JonnyB wrote: ↑Wed Mar 04, 2020 2:16 pmThe article is written by an uninformed journalist.
"World health officials say the mortality rate for COVID-19 is 3.4%"
This is not a quote because the WHO would never say something like that. The number quoted is the CFR, Case Fatality Ratio. The word mortality was added by the journalist, which is an error.
"Globally, about 3.4% of reported COVID-19 cases have died"
That is what WHO actually said, without the word mortality. That is the CFR.
Death rate is a layman's term. Generally what laymen mean by death rate is CFR, Case Fatality Ratio, not mortality.
That's why we're laymen.
And that what is causing all the confusion in the media and on this board.
People see 2%, 3% CFR, and continue to post about how 20 million people are going to die.
We don't know the mortality rate yet, because we don't know how many people get the disease and don't become confirmed cases.